My Original Theory-2: Pathological Hypothesis of Schizophrenia: First/Second World Model, Time-delay Hypothesis, Temporal profiles of Neurons
Tadashi Kon(Shinagawa Psychosomatic medicine Clinic)
〒108-0075 2-14-10-10F Kounan,Minato-Ku,Tokyo,Japan
see also http://shinbashi-ssn.blog.so-net.ne.jp/2008-05-04
In this section, the pathological hypotheses studied by Dr. Kon are introduced in
order to explain (1)the process from ARMS to onset of schizophrenia,
(2)disturbances of ego characteristic of schizophrenia,
(3)depressive moods seen with schizophrenia.
First, a pathological model of the process from ARMS to onset of
schizophrenia will be explained. What a person considers to be proper
interpersonal-distance is thought to be relative to the sensitivity of his dopamine receptors.
If a person is sensitive to dopamine, he may tend to take larger interpersonal-distances.
Some people are sensitive to dopamine from birth (for example,
those who possess excessive dopamine receptors), and they have sensitive traits
when coping with the world and others. Even if
they have the same experiences as others, they tend to release
excessive dopamine which makes them suffer. As a result, they tend to
select a lifestyle that involves fewer interpersonal relationships.
In a life in which they tend to be solitary, they may
become familiar with the arts, nature, and animals. In this way, they
grow up with sensitiveness to dopamine and they acquire a lifestyle that
helps them avoid the onset of schizophrenia. However, in adolescence, living
conditions change greatly. "They are given roles and
assignments that require interpersonal relationships,"
"they become sexually mature," and "they are placed in situations that require more assertiveness and responsibility" etc..
Life and interpersonal relationships become increasingly complicated,
and they come to the point where their withdrawal strategy is no longer sufficient.
In the midst of this, strongly stressful situations related to "sexual affairs,
money, honor, and health" cause excessive dopamine to be emitted, and combined with high sensitivity to dopamine, they face the crisis of the onset of
schizophrenia. In addition, it is easy to predict these kinds of crises exist prior
to the obvious onset. Psychotic-like experiences (PLEs, later ARMS :
at risk mental state), which are attracting attention recently,
possibly correspond to these situations.
Next is the pathological hypothesis of disturbances of the ego, which is
specific to schizophrenia. The animal's nervous system, in general, forms the loop of (1)reception of stimulation at the sensory organ→(2)conditional reaction in the
brain→(3)reaction through motor system, autonomic nervous system, etc.
→(4)real outcomes→(5)reception of stimulation at the sensory organ.
Since there is no part to confirm the generation of self-consciousness in this loop,
the sense of active control of the ego , an obvious experience in humans,
